H4N8 subtype avian influenza virus isolated from shorebirds contains a unique PB1 gene and causes severe respiratory disease in mice
Identifieur interne : 000C57 ( Main/Exploration ); précédent : 000C56; suivant : 000C58H4N8 subtype avian influenza virus isolated from shorebirds contains a unique PB1 gene and causes severe respiratory disease in mice
Auteurs : Vuong N. Bui [Japon] ; Haruko Ogawa [Japon] ; Kazuji Karibe [Japon] ; Kengo Matsuo [Japon] ; Sanaa S. A. Awad [Japon] ; Germaine L. Minoungou [Japon] ; Satoshi Yoden [Japon] ; Hiroaki Haneda [Japon] ; Lai H. Ngo [Japon] ; Shio Tamaki [Japon] ; Yu Yamamoto [Japon] ; Kikuyasu Nakamura [Japon] ; Keisuke Saito [Japon] ; Yukiko Watanabe [Japon] ; Jonathan Runstadler [États-Unis] ; Falk Huettman [États-Unis] ; George M. Happ [États-Unis] ; Kunitoshi Imai [Japon]Source :
- Virology [ 0042-6822 ] ; 2011.
Abstract
H4N8 subtype avian influenza viruses were isolated from shorebirds in eastern Hokkaido. All the isolates shared >99.7% nucleotide homology, and all the viral genes except for PB1 were highly related to those of A/red-necked stint/Australia/1/04. Thus, the isolates were regarded as PB1 reassortants. The most similar PB1 gene was identified in A/mallard/New Zealand/1615-17/04 (H4N6) with nucleotide homology of 90.9%. BALB/c mice intranasally inoculated with the H4N8 isolates developed severe respiratory disease, which eventually led to death in some mice. Virus was isolated from the lungs, and viral antigen was detected in the lungs with pneumonia. Other H4 subtype viruses tested did not cause any symptoms in mice, although these viruses were also isolated from the lungs. The PB2 gene of the H4N8 isolates contains K482R, but not the E627K or D701N substitutions. The PB1-F2 gene of the isolates consists of a 101-amino acid unique sequence, but lacks the N66S mutation.
Url:
DOI: 10.1016/j.virol.2011.11.019
PubMed: 22192630
PubMed Central: 3253874
Affiliations:
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Bui</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Ogawa, Haruko" sort="Ogawa, Haruko" uniqKey="Ogawa H" first="Haruko" last="Ogawa">Haruko Ogawa</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Karibe, Kazuji" sort="Karibe, Kazuji" uniqKey="Karibe K" first="Kazuji" last="Karibe">Kazuji Karibe</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Matsuo, Kengo" sort="Matsuo, Kengo" uniqKey="Matsuo K" first="Kengo" last="Matsuo">Kengo Matsuo</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Awad, Sanaa S A" sort="Awad, Sanaa S A" uniqKey="Awad S" first="Sanaa S. 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Ngo</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Tamaki, Shio" sort="Tamaki, Shio" uniqKey="Tamaki S" first="Shio" last="Tamaki">Shio Tamaki</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Yu" sort="Yamamoto, Yu" uniqKey="Yamamoto Y" first="Yu" last="Yamamoto">Yu Yamamoto</name><affiliation wicri:level="1"><nlm:aff id="A2">National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>National Institute of Animal Health, Tsukuba, Ibaraki 305-0856</wicri:regionArea><wicri:noRegion>Ibaraki 305-0856</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Kikuyasu" sort="Nakamura, Kikuyasu" uniqKey="Nakamura K" first="Kikuyasu" last="Nakamura">Kikuyasu Nakamura</name><affiliation wicri:level="1"><nlm:aff id="A2">National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>National Institute of Animal Health, Tsukuba, Ibaraki 305-0856</wicri:regionArea><wicri:noRegion>Ibaraki 305-0856</wicri:noRegion></affiliation></author><author><name sortKey="Saito, Keisuke" sort="Saito, Keisuke" uniqKey="Saito K" first="Keisuke" last="Saito">Keisuke Saito</name><affiliation wicri:level="1"><nlm:aff id="A3">Institute for Raptor Biomedicine, Kushiro, Hokkaido 084-0922, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Institute for Raptor Biomedicine, Kushiro, Hokkaido 084-0922</wicri:regionArea><wicri:noRegion>Hokkaido 084-0922</wicri:noRegion></affiliation></author><author><name sortKey="Watanabe, Yukiko" sort="Watanabe, Yukiko" uniqKey="Watanabe Y" first="Yukiko" last="Watanabe">Yukiko Watanabe</name><affiliation wicri:level="1"><nlm:aff id="A3">Institute for Raptor Biomedicine, Kushiro, Hokkaido 084-0922, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Institute for Raptor Biomedicine, Kushiro, Hokkaido 084-0922</wicri:regionArea><wicri:noRegion>Hokkaido 084-0922</wicri:noRegion></affiliation></author><author><name sortKey="Runstadler, Jonathan" sort="Runstadler, Jonathan" uniqKey="Runstadler J" first="Jonathan" last="Runstadler">Jonathan Runstadler</name><affiliation wicri:level="2"><nlm:aff id="A4">Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alaska</region></placeName><wicri:cityArea>Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks</wicri:cityArea></affiliation></author><author><name sortKey="Huettman, Falk" sort="Huettman, Falk" uniqKey="Huettman F" first="Falk" last="Huettman">Falk Huettman</name><affiliation wicri:level="2"><nlm:aff id="A4">Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alaska</region></placeName><wicri:cityArea>Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks</wicri:cityArea></affiliation></author><author><name sortKey="Happ, George M" sort="Happ, George M" uniqKey="Happ G" first="George M." last="Happ">George M. Happ</name><affiliation wicri:level="2"><nlm:aff id="A4">Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alaska</region></placeName><wicri:cityArea>Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks</wicri:cityArea></affiliation></author><author><name sortKey="Imai, Kunitoshi" sort="Imai, Kunitoshi" uniqKey="Imai K" first="Kunitoshi" last="Imai">Kunitoshi Imai</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22192630</idno><idno type="pmc">3253874</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253874</idno><idno type="RBID">PMC:3253874</idno><idno type="doi">10.1016/j.virol.2011.11.019</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000569</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000569</idno><idno type="wicri:Area/Pmc/Curation">000569</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000569</idno><idno type="wicri:Area/Pmc/Checkpoint">000826</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000826</idno><idno type="wicri:Area/Ncbi/Merge">000725</idno><idno type="wicri:Area/Ncbi/Curation">000725</idno><idno type="wicri:Area/Ncbi/Checkpoint">000725</idno><idno type="wicri:doubleKey">0042-6822:2011:Bui V:h:n:subtype</idno><idno type="wicri:Area/Main/Merge">000C62</idno><idno type="wicri:Area/Main/Curation">000C57</idno><idno type="wicri:Area/Main/Exploration">000C57</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">H4N8 subtype avian influenza virus isolated from shorebirds contains a unique PB1 gene and causes severe respiratory disease in mice</title><author><name sortKey="Bui, Vuong N" sort="Bui, Vuong N" uniqKey="Bui V" first="Vuong N." last="Bui">Vuong N. Bui</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Ogawa, Haruko" sort="Ogawa, Haruko" uniqKey="Ogawa H" first="Haruko" last="Ogawa">Haruko Ogawa</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Karibe, Kazuji" sort="Karibe, Kazuji" uniqKey="Karibe K" first="Kazuji" last="Karibe">Kazuji Karibe</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Matsuo, Kengo" sort="Matsuo, Kengo" uniqKey="Matsuo K" first="Kengo" last="Matsuo">Kengo Matsuo</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Awad, Sanaa S A" sort="Awad, Sanaa S A" uniqKey="Awad S" first="Sanaa S. A." last="Awad">Sanaa S. A. Awad</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Minoungou, Germaine L" sort="Minoungou, Germaine L" uniqKey="Minoungou G" first="Germaine L." last="Minoungou">Germaine L. Minoungou</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Yoden, Satoshi" sort="Yoden, Satoshi" uniqKey="Yoden S" first="Satoshi" last="Yoden">Satoshi Yoden</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Haneda, Hiroaki" sort="Haneda, Hiroaki" uniqKey="Haneda H" first="Hiroaki" last="Haneda">Hiroaki Haneda</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Ngo, Lai H" sort="Ngo, Lai H" uniqKey="Ngo L" first="Lai H." last="Ngo">Lai H. Ngo</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Tamaki, Shio" sort="Tamaki, Shio" uniqKey="Tamaki S" first="Shio" last="Tamaki">Shio Tamaki</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Yu" sort="Yamamoto, Yu" uniqKey="Yamamoto Y" first="Yu" last="Yamamoto">Yu Yamamoto</name><affiliation wicri:level="1"><nlm:aff id="A2">National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>National Institute of Animal Health, Tsukuba, Ibaraki 305-0856</wicri:regionArea><wicri:noRegion>Ibaraki 305-0856</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Kikuyasu" sort="Nakamura, Kikuyasu" uniqKey="Nakamura K" first="Kikuyasu" last="Nakamura">Kikuyasu Nakamura</name><affiliation wicri:level="1"><nlm:aff id="A2">National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>National Institute of Animal Health, Tsukuba, Ibaraki 305-0856</wicri:regionArea><wicri:noRegion>Ibaraki 305-0856</wicri:noRegion></affiliation></author><author><name sortKey="Saito, Keisuke" sort="Saito, Keisuke" uniqKey="Saito K" first="Keisuke" last="Saito">Keisuke Saito</name><affiliation wicri:level="1"><nlm:aff id="A3">Institute for Raptor Biomedicine, Kushiro, Hokkaido 084-0922, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Institute for Raptor Biomedicine, Kushiro, Hokkaido 084-0922</wicri:regionArea><wicri:noRegion>Hokkaido 084-0922</wicri:noRegion></affiliation></author><author><name sortKey="Watanabe, Yukiko" sort="Watanabe, Yukiko" uniqKey="Watanabe Y" first="Yukiko" last="Watanabe">Yukiko Watanabe</name><affiliation wicri:level="1"><nlm:aff id="A3">Institute for Raptor Biomedicine, Kushiro, Hokkaido 084-0922, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Institute for Raptor Biomedicine, Kushiro, Hokkaido 084-0922</wicri:regionArea><wicri:noRegion>Hokkaido 084-0922</wicri:noRegion></affiliation></author><author><name sortKey="Runstadler, Jonathan" sort="Runstadler, Jonathan" uniqKey="Runstadler J" first="Jonathan" last="Runstadler">Jonathan Runstadler</name><affiliation wicri:level="2"><nlm:aff id="A4">Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alaska</region></placeName><wicri:cityArea>Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks</wicri:cityArea></affiliation></author><author><name sortKey="Huettman, Falk" sort="Huettman, Falk" uniqKey="Huettman F" first="Falk" last="Huettman">Falk Huettman</name><affiliation wicri:level="2"><nlm:aff id="A4">Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alaska</region></placeName><wicri:cityArea>Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks</wicri:cityArea></affiliation></author><author><name sortKey="Happ, George M" sort="Happ, George M" uniqKey="Happ G" first="George M." last="Happ">George M. Happ</name><affiliation wicri:level="2"><nlm:aff id="A4">Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alaska</region></placeName><wicri:cityArea>Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks</wicri:cityArea></affiliation></author><author><name sortKey="Imai, Kunitoshi" sort="Imai, Kunitoshi" uniqKey="Imai K" first="Kunitoshi" last="Imai">Kunitoshi Imai</name><affiliation wicri:level="1"><nlm:aff id="A1">Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555</wicri:regionArea><wicri:noRegion>Hokkaido 080-8555</wicri:noRegion></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">H4N8 subtype avian influenza viruses were isolated from shorebirds in eastern Hokkaido. All the isolates shared >99.7% nucleotide homology, and all the viral genes except for PB1 were highly related to those of A/red-necked stint/Australia/1/04. Thus, the isolates were regarded as PB1 reassortants. The most similar PB1 gene was identified in A/mallard/New Zealand/1615-17/04 (H4N6) with nucleotide homology of 90.9%. BALB/c mice intranasally inoculated with the H4N8 isolates developed severe respiratory disease, which eventually led to death in some mice. Virus was isolated from the lungs, and viral antigen was detected in the lungs with pneumonia. Other H4 subtype viruses tested did not cause any symptoms in mice, although these viruses were also isolated from the lungs. The PB2 gene of the H4N8 isolates contains K482R, but not the E627K or D701N substitutions. The PB1-F2 gene of the isolates consists of a 101-amino acid unique sequence, but lacks the N66S mutation.</p></div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Alaska</li></region></list><tree><country name="Japon"><noRegion><name sortKey="Bui, Vuong N" sort="Bui, Vuong N" uniqKey="Bui V" first="Vuong N." last="Bui">Vuong N. Bui</name></noRegion><name sortKey="Awad, Sanaa S A" sort="Awad, Sanaa S A" uniqKey="Awad S" first="Sanaa S. A." last="Awad">Sanaa S. A. Awad</name><name sortKey="Haneda, Hiroaki" sort="Haneda, Hiroaki" uniqKey="Haneda H" first="Hiroaki" last="Haneda">Hiroaki Haneda</name><name sortKey="Imai, Kunitoshi" sort="Imai, Kunitoshi" uniqKey="Imai K" first="Kunitoshi" last="Imai">Kunitoshi Imai</name><name sortKey="Karibe, Kazuji" sort="Karibe, Kazuji" uniqKey="Karibe K" first="Kazuji" last="Karibe">Kazuji Karibe</name><name sortKey="Matsuo, Kengo" sort="Matsuo, Kengo" uniqKey="Matsuo K" first="Kengo" last="Matsuo">Kengo Matsuo</name><name sortKey="Minoungou, Germaine L" sort="Minoungou, Germaine L" uniqKey="Minoungou G" first="Germaine L." last="Minoungou">Germaine L. Minoungou</name><name sortKey="Nakamura, Kikuyasu" sort="Nakamura, Kikuyasu" uniqKey="Nakamura K" first="Kikuyasu" last="Nakamura">Kikuyasu Nakamura</name><name sortKey="Ngo, Lai H" sort="Ngo, Lai H" uniqKey="Ngo L" first="Lai H." last="Ngo">Lai H. Ngo</name><name sortKey="Ogawa, Haruko" sort="Ogawa, Haruko" uniqKey="Ogawa H" first="Haruko" last="Ogawa">Haruko Ogawa</name><name sortKey="Saito, Keisuke" sort="Saito, Keisuke" uniqKey="Saito K" first="Keisuke" last="Saito">Keisuke Saito</name><name sortKey="Tamaki, Shio" sort="Tamaki, Shio" uniqKey="Tamaki S" first="Shio" last="Tamaki">Shio Tamaki</name><name sortKey="Watanabe, Yukiko" sort="Watanabe, Yukiko" uniqKey="Watanabe Y" first="Yukiko" last="Watanabe">Yukiko Watanabe</name><name sortKey="Yamamoto, Yu" sort="Yamamoto, Yu" uniqKey="Yamamoto Y" first="Yu" last="Yamamoto">Yu Yamamoto</name><name sortKey="Yoden, Satoshi" sort="Yoden, Satoshi" uniqKey="Yoden S" first="Satoshi" last="Yoden">Satoshi Yoden</name></country><country name="États-Unis"><region name="Alaska"><name sortKey="Runstadler, Jonathan" sort="Runstadler, Jonathan" uniqKey="Runstadler J" first="Jonathan" last="Runstadler">Jonathan Runstadler</name></region><name sortKey="Happ, George M" sort="Happ, George M" uniqKey="Happ G" first="George M." last="Happ">George M. Happ</name><name sortKey="Huettman, Falk" sort="Huettman, Falk" uniqKey="Huettman F" first="Falk" last="Huettman">Falk Huettman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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